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INTEGRIN ALPHA6BETA1
Descriptors Found:
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DeCS
Descriptor
English
:
Integrin alpha6beta1
Descriptor
Spanish
:
Integrina alfa6beta1
Descriptor
Portuguese
:
Integrina alfa6beta1
Tree Number:
D12.776.395.550.625.419
D12.776.543.550.625.419
D12.776.543.750.705.408.850.674
D12.776.543.750.705.675.514
D12.776.543.750.705.876.500
Definition
English
:
A cell surface receptor mediating
cell adhesion
to the
EXTRACELLULAR MATRIX
and to other cells via binding to
LAMININ
. It is involved in cell
migration
,
embryonic development
, leukocyte activation and tumor cell invasiveness.
Integrin alpha6beta1
is the major
laminin
receptor on PLATELETS;
LEUKOCYTES
; and many
EPITHELIAL CELLS
, and ligand binding may activate a number of
signal transduction
pathways.
Alternative splicing
of the cytoplasmic domain of the alpha6 subunit (
INTEGRIN ALPHA6
) results in the formation of A and B isoforms of the heterodimer, which are expressed in a tissue-specific manner.
History Note
English
:
2003; use INTEGRIN ALPHA6BETA1 (NM) 1992-2002
Allowable Qualifiers
English
:
AD
administration & dosage
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PH
physiology
RE
radiation effects
TU
therapeutic use
UL
ultrastructure
Record Number:
37451
Unique Identifier:
D039121
Occurrence in VHL
:
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DeCS
CID-10
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